Analgesic and Anti-inflammatory activity of fruit extract phytocompounds of Chloroxylon swietenia DC
Ravishankara B, Riaz Mahmood, V Krishna, Vinay Kumar NM, Ajith S
Chloroxylon swietenia is a popular medicinal plant that is used traditionally in indigenous medicinal practices in India and Sri Lanka to treat wounds, relieve pain and inflammation. However, there are no reports found on the scientific evaluation of C. swietenia fruits for their analgesic and anti-inflammatoryactivities. The present study was aimed to check the analgesic and anti-inflammatoryactivities of fruit ethanol extract of C. swietenia in various experimental models in rats. Analgesic activity was determined using the tail immersion, hot plate methods, and writhing test in acetic acid-induced rats, whereas anti-inflammatory studies were performed in carrageenan-induced inflammation in rats. The results of increased fruit ethanol extract concentration i.e. 500 mg/kg body weight dose level have shown promising effects on all selected experimental models, in the tail immersion test it showed withdrawal time of 7.59 ±0.07 sec. while standard Diclofenac treated group showed 9.49 ±0.17 sec, similarly for hot plate method it showed 10.43 ±0.05sec. which is near to standard Diclofenac treatment group 11.34 sec, and in acetic acid-induced writhing 42.33±1.86writhes was observed in 500mg/kg b. w. treated group whereas 31.67±1.45writhes were recorded in standard Diclofenac treated group. Anti-inflammatory activity of carrageenan-induced rats, paw edema, and swelling was under control and effectively reduced in the fruit ethanol extract-treated group noticeably in comparison with the control group. This study concludes that Chloroxylon swietenia fruit extract possesses analgesic and anti-inflammatory potential which is an indication of the traditional claim of this plant in the Indigenous system of medicine which might be due to the presence of a therapeutic group of phytochemicals i.e. phenolic, alkaloids, tannins, and steroids, etc.