The present study was aimed at the estimation of the antioxidant potentialities of leaf homogenate of Pisonia alba. The results of the reducing power assay showed a steady increase in the reducing power, with increase in the concentration of the leaf homogenate. Similarly the free radical scavenging activity also showed a dose dependent relation, ie the scavenging of DPPH free radical and nitric oxide free radical increased with increase in the concentration of the homogenate. The antioxidant potential expressed by the leaf homogenate of Pisonia alba during the current study may be due to the presence of diverse types of phytochemical constituents such as flavanoids, phenolics, oxalic acid and tannins. Hence it may be concluded that Pisonia alba can play an important role in the reduction as well as prevention of free radical induced pathogenesis.