Evaluation of antifungal activity and phytochemical analysis of selected plant extracts against Malassezia Furfur
Suguna SR, Tessy Anu Thomas, Sharmila Tirumale
The fungus Malassezia furfur is lipophilic dimorphic yeast, widely accepted as the causative agent of superficial skin infections like pityriosis versicolor, seborrhoeic dermatitis, dandruff and atopic dermatitis. The currently available synthetic drugs possess limitations, due to this drawback of conventional drugs; attention is shifted towards herbal remedies with medicinal plants as alternative drugs. The study was carried out to evaluate the antifungal activity of nine selected plant extracts of Sida cardifolia, Senna alexandrina, Mentha citrata, Trigonella foenumgraecum, Pelargonium geaveolens, Nelumbo nucifera, Datura stramonium, Tagetes erecta and Lantana camara with ketoconazole as the positive reference standard. The anti-malassezial efficacy was tested using different solvent extracts and the preliminary screening of plant extracts was determined by the Kirby Bauer disc diffusion method and Minimum Inhibitory concentration was determined by the micro broth dilution method wherein the MIC was showcased to be 0.78mg/ml, 0.156 mg/ml and 1.25mg/ml respectively. The preliminary phytochemical analysis of secondary metabolites by standard chemical methods revealed the presence of different secondary metabolites. Such as phenolics, alkaloids, terpenoids, saponins, flavonoids, tannins.