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VOL. 6, ISSUE 2 (2021)
in vivo anxiolytic and locomotor activity of water extract of mung beans seeds in swiss albino mice
Authors
Sonali V Uppalwar, Vandana Garg, Shrikant Joshi, Rohit Dutt
Abstract
Mung beans seeds have been recognized as health-promoting pulses to alleviate anxiety and other related disorders. Though, being an important functional food, the antianxiety activity of these seeds is not explored yet. Thus this research finalizes the anxiolytic action of various extracts of the Mung Beans seeds. However, extractions of Mung bean seeds have been carried by the triple maceration method and different extracts of solvents like petroleum ether, chloroform, ethanol, and water were prepared and dried. Besides, different doses of extracts viz. 50, 100, and 150 mg/kg.(p.o.) were given to female Swiss Albino mice as compared to standard drug diazepam 2mg/kg.(i.p) and their behavior was monitored on EPM and light & dark test model while the motor movement was assessed using a photoactometer; Although, each isolate was found to be safe with no deaths in female Swiss Albino mice when giving out orally with a dose of 1000 mg/kg(p.o.). Among all fraction, water extract (150mg/kg, p.o.) of the Mung bean seeds significantly boosted the entries and average spent time in the open arms in the EPM test along with progress in time spent as well significantly rise in duration of immobility and total of grade crossing inside the light and dark chamber but no expressive changes had been revealed in locomotor activity. These outcomes suggested that the aqueous extract at the dose of 150 mg/kg had shown anxiolytic effects and justify the traditional utilization of Mung bean seeds in the management of neurological syndromes.
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Pages:535-541
How to cite this article:
Sonali V Uppalwar, Vandana Garg, Shrikant Joshi, Rohit Dutt "<em>in vivo</em> anxiolytic and locomotor activity of water extract of mung beans seeds in swiss albino mice ". International Journal of Botany Studies, Vol 6, Issue 2, 2021, Pages 535-541
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