Chemical Constituents and antidiabetic activity of Cordia dichotoma a valuable source for bioactive compounds
Mathiyalakan Madhubala, Govindarajalu Santhi
Oxidative stress plays a major role in diabetic physiopathology; hence, the interest of using natural antioxidants as therapeutic tools exists. The aim of this study was the evaluation of in vitro anti diabetic and inhibitory potential of organic extracts from Cordia dichotomaleaves against key enzymes linked to hyperglycemia. The α-amylase and α-glucosidase inhibitory activities were investigated using an invitro model. Moreover, phytochemical analysis of tested extracts was carried out. The methanol fraction of this herb exhibited the IC50=168.85µg/mL and IC50=93.91µg/mL, respectively. However, the methanol fraction possessed the strongest inhibitory effect towards -Glucosidase ((IC50 295.38 µg/ml). Furthermore, the results showed high levels of phenolic content. The results showed that this plant could be a significant source of medically important natural compounds.