In this study shows a presence of secondary metabolites in the crude extract of methanolic from Mentha arvensis such as steroids, reducing sugar, sugars, alkaloids, phenolic compound, flavonoids, saponins, tannins and amino acids but the absence of Catechins. These secondary metabolites are used for different therapeutic applications.For example tannins possess several mechanisms: antioxidative, antiviral, antitumor, antithrombogenic and anti-inflammatory properties.Reduction of silver ions in aqueous solution of silver complex during the reaction with plant extract have been confirmed by color changes. The UV spectral analysis of silver about the SPR bands at 330nm is the absorbance is emitting from silver nanoparticles is shown.The SPR bands are corresponds to surface Plasmon vibration resonance in the AgNPs, whereas the peak range are occurs due to excitation of SPR bands formation.Figure 5 shown the absorption peak ranges in FTIR spectra analysis of synthesized AgNPs from plant extract. The peak of reduced silver at 1699 cm−1.The presence of bonds due to C=C stretching (around 1621cm−1) which predicts the presence of alkenes, Stretching of Polyols C-O (around 1159cm−1),Stretching of 1° amine N-H (around 3377 cm−1),Stretching of carbonyl C=O (1735 cm−1). The bio constituents are interacting with silver ions and mediate the reduction process with their functional groups. In SEM micrograph shown a particle size of silver particle from extract are formed at 1000 nm to 10000 nm. The comparative study of antimicrobial activity and antibiotic activity of synthesized silver nanoparticle from Mentha arvensis.The antimicrobial activity are more active against the tested microorganisms shown in.Possess a better inhibition while comparing to the tested antibiotics.Finally, here we concluded that extract could be consider as an antibiotic.Instead of antibiotic drugs, this plant extract having the capacity to cure a disease.