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VOL. 6, ISSUE 3 (2021)
Preliminary phytochemical analysis and evaluation of cytotoxic profile of leaf and bark of Garcinia morella (Gaertn.) Desr. from Western Ghats
Authors
Vikas HR, Poornima D
Abstract
Phytochemicals are naturally occurring compounds in plants, play a very crucial role in protecting plants against diseases. Preliminary phytochemical analysis and cytotoxic studies in the leaf and bark of Garcinia morella collected from the Western Ghats were carried out. Hexane, chloroform, petroleum ether, water, and hydroalcohol were used for the extraction. The preliminary qualitative phytochemical analysis revealed the presence of alkaloids, flavonoids, tannins, terpenoids, phenols, carbohydrates, glycosides, saponins, and volatile oil. In the present study, the cytotoxic effect of hexane, chloroform, petroleum ether, water, and hydroalcoholic extract of leaf and bark was evaluated on HCT-116 using 3-(4, 5-dimethylthiazol-2-yl) 2, 5-diphenyl tetrazolium bromide (MTT) assay. The hydroalcoholic extract showed a remarkable decrease in the viable cell populations. Based on the observed results we could conclude that HAGM has a potent cytotoxic effect on cancer cells. Further detailed exploration is required to confirm its chemotherapeutic efficacy in different cancer cell lines. The chemical composition and medicinal properties of G. morella have already been studied and recorded. However environmental conditions influence the variations and accumulations of phytochemicals in plants. The type of solvents used in the extraction process will help other researchers to decide solvent composition for further work on the 7 on the leaf and bark of Garcinia morella.`
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Pages:716-720
How to cite this article:
Vikas HR, Poornima D "Preliminary phytochemical analysis and evaluation of cytotoxic profile of leaf and bark of <em>Garcinia morella</em> (Gaertn.) Desr. from Western Ghats ". International Journal of Botany Studies, Vol 6, Issue 3, 2021, Pages 716-720
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