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VOL. 6, ISSUE 3 (2021)
Evaluation of neuropharmacological profile of aqueous extract of Pterocarpus marsupium
Authors
Syed Safiullah Ghori, Fouzia Tehseen, Sarwath Jahan, Qurrath Ul Ain Sana, Asra Begum
Abstract
This study was conducted to evaluate the neuropharmacological profile of aqueous bark extract of Pterocarpus marsupium which is traditionally used for medicinal purpose. The general behaviour studies were assessed by the method of Irwin in wistar rats. The paralytic activity was analysed by inclined plane test in mice. Hypnotic potentiation was evaluated by thiopental sodium induced sleeping time in albino mice. The analgesic activity was determined by using hot plate method in mice. The locomotor activity was assessed by using actophotometer in mice. The anticonvulsant activity was analysed by using maximal electroshock method by using an electro convulse meter in rats. The statistical analysis of the data was done by anova and students t test. The data was expressed as mean +/_ SEM. Pterocarpus marsupium showed significant CNS inhibitory activity evidenced by decreased locomotor activity. It shows hyperactivity of animals towards external stimuli like touch and noise. This research also revealed other possible side effects of the drug. It can be concluded that Pterocarpus marsupium extract has CNS inhibitory effect in mice and rats.
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Pages:541-545
How to cite this article:
Syed Safiullah Ghori, Fouzia Tehseen, Sarwath Jahan, Qurrath Ul Ain Sana, Asra Begum "Evaluation of neuropharmacological profile of aqueous extract of <em>Pterocarpus marsupium</em> ". International Journal of Botany Studies, Vol 6, Issue 3, 2021, Pages 541-545
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