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VOL. 6, ISSUE 3 (2021)
Mutagenic potentialities of some drugs misuse using Vicia assay
Authors
Magda Ibrahim Soliman, Shereen S Metwaaly, Mohamed Fathy Daw
Abstract
Addiction (drug misuse) is considered as a serious disease like other disease as heart disease that disrupted and changed the normal functions for all organs in the body with very dangerous harmful side effects and if this disease not treated it could be led to death. Tramadol, Fluoxetine and Calmepam are opioid drugs affect harmfully in biological actions in human body. Three concentrations from each drug were used to study their mutagenic effect and cytotoxicity using Vicia faba test plant. The highest increase in MI was recorded in Fluoxetine 80 mg with value 29.88% followed by 600 mg of Tramadol with value 25.83 %. The highest phase index increase in metaphase stage was observed in Calmepam 18 mg with value of 52.45%, while the highest percentage of abnormalities were reported in Calmepam at treatment 18 mg with value 56.64%. Various types of aberrations were illustrated as cytomix, micronucleus at interphase and prophase, whereas disturbed, oblique, non-congression, stickiness were present at metaphase, finally anaphase and telophase stages included late separation, diagonal, bridges and laggard aberration.
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Pages:730-738
How to cite this article:
Magda Ibrahim Soliman, Shereen S Metwaaly, Mohamed Fathy Daw "Mutagenic potentialities of some drugs misuse using <em>Vicia</em> assay ". International Journal of Botany Studies, Vol 6, Issue 3, 2021, Pages 730-738
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