Among the different wild edible ferns, Diplazium esculentum (Family: Athyriaceae), is one of the most popular species ranked as a pharmacologically diverse ethnomedicinal plant owing to its medicinal usage of circinate part and young leaves. The present article is the first comprehensive review on the In-vitro propagation and phytochemistry of this edible fern. The antimicrobial, antioxidant, immunomodulatory, neuro modulatory, anti-fertility, cytotoxic etc. are the most thoroughly studied pharmacological activities of the D. esculentum. This fern is consumed traditionally depending upon its indigenous nutritive and medicinal value in different areas of the world. It is a seasonal underutilized vegetable which may act as a potential functional food and also reservoir of important compounds such as alkaloids, flavonoids, saponins, Terpenoids. This fern is also rich in various micronutrients including phosphorus, calcium, iron, vitamins C, A and dietary fibres. Hence, malnutrition can be overcome by using this wild edible to some extent. The fruitful In-vitro multiplication of this fern was also reviewed while its genetic diversity is less inferred.