This study explains with the GC MS analysis of one Ayurvedic polyherbal formulation, Patoladi Kwatha Churna used the treatment of psoriatic disease. The prepared formulation of "Patoladi Kwatha Churnam" was extracted with ethanol and analyzed by GC- MS identification of different compounds. Some important molecules such as bicyclo [2.2.2] oct-2-, 1,2,3,6-tetramethyl, benzene heptanoic acid, 4,5-dioxo-, 4-Bromo-butyl ester, tricyclo [3.3.1.1(3,7)] decane-2,6-dione, 4-hydroxy-, octan-2-one, 3,6-dimethyl-, 10-methyl-e-11-Tridec-1-of acetate, cyclohexane, 4,4-dimethyl-, 5-cyclooctene-1,2-diol, diacetate, 1-adamantane methylamine, alpha,-methyl-, 1-benzyl-4-nitroimidazole, Sclareoloxide(cis-b/c), 1-cyclohexene, 1-cyano-4-isopropenyl-, 2,3-Epoxyhexanol, etc. these molecules indicate the medicinal roles which are similar to the medicinal roles attributed to the "Patoladi Kwatha Churnam" in an Ayurvedic formulation.