Diospyros is the most versatile genus belonging to family Ebanceae. It comprises more than 500 species distributed in tropical and warm temperate regions of the world. These species have been used in the traditional medical systems of several countries. Therefore, the Diospyros species drawn the attention of research investigators to analyze their phytochemical profile and biological activities. The present study relates to phytochemical screening of Diospyros chloroxylon leaf extracts through HPLC technique. Twelve phenolic and flavonoid compounds (viz., (1) Apigenin-6, 8-di-C-glucopyranoside (2) Kaempferol- 3, 7-di-O-rhamnosid (3) Kaempferol-7-O-rhamnoside (4) Isorhamnetin (5) Isorhamnetin-3-O-dihexoside (6) Scutellarein7-O-β-D-glucopyranoside (7) gallic acid (8) Quercetin (9) Kaempferol (10) Rutin (11) (−) epigallocatechine and (12) Epicatechin gallate) were identified in the aqueous and methanolic leaf extracts of Diospyros chloroxylon. The above compounds confirm the medicinal potential of Diospyros chloroxylon and emphasizes the need of further pharmacological studies in this species.