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VOL. 6, ISSUE 5 (2021)
Effect of in vitro antidiabetic and anti-obesity activities of hot water extrect of Tephrosia purpurea
Authors
S Vadivelan, S M Kirubhakaran, T Sarojini, S Mathukumar
Abstract
This study evaluated potential antidiabetic and antiobesity properties in vitro of selected medicinal plants. The hot water extract of Tephrosia purpurea were tested for total antidiabetic capacity using inhibition of alpha- amylase and glusidase capacity assays, followed by anti-obesity activity of inhibition of lipase. Hot water extract of T. purpurea had the highest total phenolic content (61.34 µg/ml of GAE/L) and flavonoid content of 46.56 µg/ml Rutin/L) and inhibition of alpha- amylase and alpha-glucosidase (EC50 = 62.28 µg/ml) and EIC50 = 76.32 µg/ml) respectively compared to acarbose. Similarly, Hot water extract of T. purpurea also exhibited significantly lower EC50 values for the percentage inhibition of lipase EC50 = 61.56 µg/ml compared to orlistate (EC50 = 66.98 µg/ml) (p ≤ 0.05). Phenolic and flavonoid content present in this plants have the potential to use in managing type 2 diabetes and obesity.
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Pages:878-882
How to cite this article:
S Vadivelan, S M Kirubhakaran, T Sarojini, S Mathukumar "Effect of <em>in vitro</em> antidiabetic and anti-obesity activities of hot water extrect of <em>Tephrosia purpurea</em> ". International Journal of Botany Studies, Vol 6, Issue 5, 2021, Pages 878-882
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