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VOL. 6, ISSUE 5 (2021)
Effect of Begonia malabarica fraction on streptozotocin induced insulitis and β-cell damage
Authors
P Pandikumar, S Muthukanagavel, S Mutheeswaran, P Ganesan, S Ignacimuthu
Abstract
The stems of Begonia malabarica Lam. (Begoniaceae) is used as a food supplement and remedy for diabetes by the Malasar tribes in Tamil Nadu. The work assessed the protective effect of a bioactive fraction from B. malabarica on pancreatic β-cells of Multiple Low Dose of Streptozotocin (MLDS) induced diabetic mice. The animals were treated orally either with vehicle or with 50-200 mg/kg of the bioactive fraction (EtSF-BM) from the day of diabetes induction upto 21 days. Biochemical parameters such as glucose, MDA, MPO, insulin as well as pancreatic histopathology were assessed. By the end of the study 80% of the animals in control group were diabetic; while EtSF-BM (200 mg/kg) treatment reduced it to 20%. The treatment with EtSF-BM at 200 mg/kg concentration significantly reduced MDA (65%) and MPO (45.1%) levels. The insulin level of the pancreatic tissue was significantly increased by 2.3 fold at 200 mg/kg concentration. Histological analysis also revealed a decrement in insulitis. The results of our experiment suggest that the antidiabetic effect of B. malabarica might be through β-cell protection. Further experiments are required to assess potential application of B. malabarica as a food supplement and remedy for diabetes.
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Pages:1213-1218
How to cite this article:
P Pandikumar, S Muthukanagavel, S Mutheeswaran, P Ganesan, S Ignacimuthu "Effect of <em>Begonia malabarica</em> fraction on streptozotocin induced insulitis and β-cell damage ". International Journal of Botany Studies, Vol 6, Issue 5, 2021, Pages 1213-1218
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