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VOL. 6, ISSUE 5 (2021)
Evaluation of in vitro antidiabetic activity of two different varieties of finger millet (Eleusine coracana - Ragi) and its formulation
Authors
Jayaprada L, Jeyaraj M
Abstract
Diabetes mellitus is a chronic disorder caused by partial or complete insulin deficiency, resulting in hyperglycaemia leading to acute and chronic complications. α-amylase and α-glucosidase digest the carbohydrates and increase the postprandial glucose level in diabetic patients. Inhibiting the activity of these two enzymes can control postprandial hyperglycemia, and reduce the risk of developing diabetes. However, there is limited information available on the presence of α-amylase and α-glucosidase inhibiting compounds. In the current study, the ethanol extracts of Eleusine coracana varieties (powder of C014, C015 and flake of C014, C015) and its formulation (1:1 ratio of C014, C015 powder and 1:1 of ratio C014, C015 flake) were tested for α-amylase and α-glucosidase inhibiting activities in vitro. The ethanol extracts of Eleusine coracana varieties inhibited the activity of α-amylase and α-glucosidase through competitive inhibition and compared with standard as Acarbose. The order of antidiabetic activity was observed as C014:C015 flake, C014:C015 powder, C014 flake, C014 powder and C015 powder variety. The observed effects may be associated with the presence of flavonoids, saponins, and alkaloids. Among the various Eleusine coracana varieties and its formulation, C014 flake variety and C014:C015 flake formulation has potential antidiabetic activities were observed.
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Pages:421-424
How to cite this article:
Jayaprada L, Jeyaraj M "Evaluation of <em>in vitro</em> antidiabetic activity of two different varieties of finger millet (<em>Eleusine coracana</em> - Ragi) and its formulation ". International Journal of Botany Studies, Vol 6, Issue 5, 2021, Pages 421-424
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