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VOL. 6, ISSUE 5 (2021)
Evaluation of safety assessment of two different varieties of pearl millet (Pennisetum glaucum-Kambu) and its formulation in albino rats
Authors
R Sakthi, M Jeyaraj
Abstract
The concept of food as medicine has evolved and been in practice a long time ago. Before used as medicine, drugs from plant origin must be ensured as safe. The present work focused to study the in vivo toxicity effects of the petroleum extracts of Pennisetum glaucum (Pearl millet) varieties (powder of C010, Nattu kambu and flake of C010, Nattu kambu) and its formulation (1:1 ratio of C010, Nattu kambu powder and 1:1 of ratio C010, Nattu kambu flake) were carried out in vivo on albino rats. Seven groups of albino rats were treated with five different doses of the petroleum extracts of Pennisetum glaucum varieties (powder of C010, Nattu kambu and flake of C010, Nattu kambu) and its formulation (1:1 ratio of C010, Nattu kambu powder and 1:1 of ratio C010, Nattu kambu flake) orally for 14 days. General appearance and behavior were observed for 14 consecutive days. Acute toxicity studies results showed that up to the tested dose of 2000 mg/kg bwt in extract treatments, throughout the 14 days of treatment, the extract does not produced any toxicity symptoms. No toxicity related symptoms were observed in doses of Pearl millet powder and formulation extracts treated rats groups. So the LD50 values of the tested Pearl millet extracts were more than 2000 mg/kg bwt.
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Pages:504-507
How to cite this article:
R Sakthi, M Jeyaraj "Evaluation of safety assessment of two different varieties of pearl millet (<em>Pennisetum glaucum</em>-Kambu) and its formulation in albino rats ". International Journal of Botany Studies, Vol 6, Issue 5, 2021, Pages 504-507
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