The field experiment was carried out in the farmer’s field, Vittukkatti village, Thiruthuraipoondi Taluk, Thiruvarur district, during June – October 2020 to assess the effect of Nano N, P, K and ZnSO4 on rice production. The experiment was laid out in Randomized Block Design (RBD) with nine treatments viz., T1⁻control,T2⁻100% RDF (120: 40:40 N, P, K kg ha-1), T3⁻100% Nano N, P, K (25 kg ha-1),T4⁻75% RDF + 25% Nano N, P, K + ZnSO4 @ 25 kg ha-1 (Soil application),T5⁻75% RDF + 25% Nano N, P, K + ZnSO4 @ 0.5% (foliar application),T6⁻50% RDF + 50% Nano N, P, K + ZnSO4 @ 25 kg ha-1(soil application),T7⁻50% RDF + 50% Nano N, P, K + ZnSO4 @ 0.5% (foliar application),T8⁻25% RDF + 75% Nano N, P, K + ZnSO4 @ 25 kg ha-1(Soil application),T9⁻25% RDF + 75% Nano N, P, K + ZnSO4 @ 0.5% (foliar application)replicated thrice. The experiment results proved that the combined application of conventional and Nano N, P, K along with the different methods of ZnSO4 application significantly influenced most of the growth and yield parameters of rice. Among the different treatments tried, application of 50% RDF + 50% Nano N, P, K + ZnSO4 @ 25 kg ha-1(T6) was showed supremacy on improving growth components (plant height (95.2 cm), number of tiller hill-1 (25), leaf area index (5.96), dry matter production (13893 kg ha-1), crop growth rate (5.92)) and yield attributes (productive tillers (375), number of filled grains panicle-1(127)). The lowest values of plant height (71.4cm) at harvest stage, productive tillers m-2 (176), number of filled grains panicle-1 (98) were observed in control. Improved growth and yield parameters enhanced the yield of rice with the application of 50% RDF + 50% Nano N, P, K and ZnSO4 soil application @ 25 kg ha-1(T6) with the higher grain yield of 7635 kg ha-1 and straw yield of 8609 kg ha-1. It can be concluded that the continuous application of Nano and conventional fertilizers improved the plant growth and yield of rice significantly.