The present study is to evaluate the antibacterial activity of Moringa oleifera leaf in different solvent extracts such as ethanol, methanol, acetone and diethyl either. Moringa oleifera is an ever green medicinal plants tested again six gram negative bacteria such as Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa, Proteus mirabilis, Serratia marcens, Shigella flexneri,and gram positive bacteria such as Enterococcus faecalis, Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, Staphylococcus albus and Streptococcus agalactiae were taken for this study. Based on the results described we may conclude that ethanolic and methanolic extract of Moringa oleifera (Lam.) possess significant antimicrobial activity. The results obtained also revealed that Moringa oleifera (Lam.) could serve as a useful source of new antibacterial agent.