Lorenz Hiltner, in 1904, described the term rhizosphere for the first time, hence the rhizosphere is the area of soil, that is to say, immediately near the root surface, in which the microbial population of soil is influenced by the chemical events of plant roots that exude substances that aid as nutrients for rhizosphere microbial growth. In this way, the rhizosphere is considered a very vital zone for plant growth and development, disease resistance, and nutrient recycling. Billions of microbes are present in a handful of soil, which comprises fungi, bacteria, viruses, nematodes, archaea etc., which differ according to plant species, root zone, growth stage of the plant, along with the incidence of stress and occurrence of disease. The root exudates released from the roots create a different environment for microbial growth in the rhizosphere than in the bulk soil. The plant-microbial association in the rhizosphere has a positive impact on the development of the rhizosphere-microbiota population, inducing production of auxins and cytokinin (the growth-promoting hormones), increasing accessibility of nutrients, stimulating host defence criteria, sustaining agriculture, inducing tolerance to stress, and controlling pathogenesis through antagonism. Hence, biofertilizers and biocontrol agents can be formulated from these beneficial plant growth-promoting (PGP) microbes. Along with this, several microbes are also violent towards plants and, therefore, show pathogenic activity. Hence, this review summarizes the natural associations between plants and microbes in the rhizosphere and discusses how their relationship affects plants both beneficially and negatively.