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VOL. 6, ISSUE 6 (2021)
Brine shrimp lethality assay of some selected medicinal plant flowers in polar and Non-polar solvents
Authors
Narwade Keshav B, Vishal R Marathe
Abstract
The present research work was conducted to investigate the in-vitro Brine Shrimp Lethality Assay (BSLA) of some selected plant flowers extract in a polar and non-polar solvent and correlate cytotoxicity results with known pharmacological activities of the plants. Cytotoxicity was evaluated in terms of LC50 (lethality concentration). The LC50 of an agent is the concentration, which kills, or inactive 50% of the test animal. LC50 is inversely proportional to the toxicity of a compound, i.e., the lower is the LC50, the higher is the cytotoxicity. Aqueous extract of Catharanthus roseus 150 LC50 (µg/ml) and methanolic extract of Tamarindus indica 236.66 LC50 were considered for the bioactive compound shown cytotoxicity correlated with the anticancer property. Whereas chloroform extract of Calotropis gigantia with greater than 1000 LC50 value is considered as toxic activity. It indicated that this bioassay has a good correlation with the human solid tumor cell lines.
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Pages:572-574
How to cite this article:
Narwade Keshav B, Vishal R Marathe "Brine shrimp lethality assay of some selected medicinal plant flowers in polar and Non-polar solvents ". International Journal of Botany Studies, Vol 6, Issue 6, 2021, Pages 572-574
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