Tyrosinase is a key enzyme in the process of melanin synthesis, which is responsible for pigmentation of skin, eye, and hair. Various natural skin whitening agents are available as tyrosinase inhibitors that possess phenolic moiety. Aim of the work was to assess the inhibitory effect of phenolic compounds against tyrosinase enzyme with molecular docking studies using AutoDock tools. Polyphenols the secondary metabolites in plants are required for normal cellular processes and are also formed in response to adverse climatic conditions or in presence of environmental stressors. These phytoconstituent are abundantly present in plants and dietary items like fruits, cereals, vegetables and seedsknown for their antioxidant properties. Among the six polyphenols studied using In silico tools against tyrosinase enzyme, the docking studies showed four phyto constituents, quercetin, kaempferol, chlorogenic acidand ferulic acid with high binding energy when compared with standards like kojic acid, arbutinastyrosinase enzyme in hibitors. The ADME profile of the compounds were calculated using the Swiss ADME web tools, and indicated adequate values related to bioavailability. Moreover, drug-likeness levels of the compounds were also predicted according to the Lipinski rules along with solubility parameters.