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VOL. 6, ISSUE 6 (2021)
In vitro assessment of antioxidant and anticancer activities of Capparis Zeylanica L. leaf extracts against human breast cancer (MCF-7)
Authors
Sathish Kumar R, Anburaj G, Mageshkumar R, Subramanian A, Vasantha S
Abstract
The preliminary phytochemical analysis of leaf extract of Capparis zeylanica L. revealed the presence of secondary metabolites such as Phenol, Alkaloids, Saponins, Anthroquinones, Flavonoids, Phlobatannins, Protein, Steroids, Tannins and Terpenoids. The anti-oxidant activity has been studied after the phytochemical analysis of the leaf extract by using DPPH and Superoxide radical scavenging assay. Based on the studies on phytochemical activity and anti-oxidant activity by using various leaf extracts such as Aqueous, Acetone, Ethyl acetate and Methanol extract, we put forward methanol extract for the anti-cancer studies due to its enhanced activities. Different concentrations of methanol leaf extract were exposed to MCF-7 cancer cell lines. Three replicate samples OD value were measured at 570nm and the IC50 value of the sample found at 132.3μg/ml. Increased concentration of the leaf extracts increased the mortality which denoted the decreased cell viability of the cancer cells. The lowest cell viability of MCF-7 cancer cell found in 500μg/ml.
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Pages:1301-1305
How to cite this article:
Sathish Kumar R, Anburaj G, Mageshkumar R, Subramanian A, Vasantha S "<i>In vitro</i> assessment of antioxidant and anticancer activities of <em>Capparis Zeylanica</em> L. leaf extracts against human breast cancer (MCF-7) ". International Journal of Botany Studies, Vol 6, Issue 6, 2021, Pages 1301-1305
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