Medicinal plants are gifts from nature to treat infinite number of diseases between human beings, play an essential role in local communities all over the world. Withania somnifera, plant of Solanaceae family is an important healing short-woody evergreen shrub recognized as Ashwagandha that naturally growing at Braj region of western Uttar Pradesh. It is also known as Prince of Herbs in Indian system of Ayurveda because it has a markedly broad range of therapeutic effects and provides potential benefits for human healthiness. Several parts of W. somnifera include root has many biochemical activity and wonderful medicinal properties which used in Indian system of Ayurveda and Siddha and Unani system of medicine from ancient times to treat of senile dementia, ulcers, bronchitis, asthma, emaciation, leukoderma, diarrhea, liver disease and insomnia by local people. Ashwagandha root is among the prominent part used in Ayurveda, a holistic system of medicine that originated in India. Information used in present review was obtained from several books, available articles and databases using many search engines. The key objective of this review on W. somnifera will serve as a database is an effort to distribute comprehensive information about the botanical explanation, pharmaceutical activity, medicinal impertinence and traditional uses of Ashwagandha plant.