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VOL. 6, ISSUE 6 (2021)
Okra Gum from Abelmoshus esculentus fruit pods: Isolation, Characterisation and Utilisation for the Formulation of Seaweed alginate based Antidiabetic Drug Loaded Gelibeads
Authors
Annapoorani Arjunan, M V Kumudhavalli, A Rahamathunisa, Saravanan Muniyappan, Kumar Mohan, B S Venkateswarlu
Abstract
The present work is aimed to isolate and characterise of Okra Gum from Abelmoshus esculentus unripe fruit pods. Okra gum was incorporated with seaweed alginate and antidiabetic drug loaded gelibeads were prepared by ionotropic gelation method. Biosynthetic polymers were also used to formulate gelibeads using calcium chloride as the crosslinking agent. The Metformin HCl- Okra gum compatibility studies were performed using FTIR. The prepared gelibeads showed good micromeritics properties. Six formulations were prepared by varying the drug polymer ratio. Drug release from Gelibead formulations with a Drug Okra gum in the 1:1 ratio showed good in vitro dissolution profile. Gastro-retentive mucoadhesive properties of the gelibeads were proved by in vitro wash off test. Okra gum was a proven antidiabetic molecule when incorporated with Metformin HCl gives a good synergistic activity in the treatment of Diabetes mellitus. The prepared gelibeads will serve as a novel controlled release formulations as a once daily dosage form in the treatment of Diabetes mellitus.
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Pages:550-556
How to cite this article:
Annapoorani Arjunan, M V Kumudhavalli, A Rahamathunisa, Saravanan Muniyappan, Kumar Mohan, B S Venkateswarlu "Okra Gum from <em>Abelmoshus esculentus</em> fruit pods: Isolation, Characterisation and Utilisation for the Formulation of Seaweed alginate based Antidiabetic Drug Loaded Gelibeads". International Journal of Botany Studies, Vol 6, Issue 6, 2021, Pages 550-556
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