Alzheimer's disease is a catastrophic form of cognition that impairs a patient's capacity to think critically and hold a conversation. This is also termed as senile dementia, and is the most neurodegenerative disease. It mostly affects persons over the age of 65 year, however there have been found middle age people (age within 30-60 year) also experienced Alzheimer's complication. Medicinal herbs have been demonstrated to be important in improving the functionality of nervous system in a number of scientific studies. Phytochemicals from the Spatholobus genus plant were tested as folk remedies to the acetylcholinesterase enzyme (1ACJ) which triggers Alzheimer's disease in this study. We discovered that Medicarpin (interaction energy -9.9 Kcal/mol) is the best of the four molecules examined from S. suberectus for interacting with protein 1ACJ. We reported that Prestegane B has a higher binding potential to the target protein 1ACJ, i.e., -10.2 Kcal/mol with two hydrogen bonds in contact, than the other five molecules studied from S. sinensis. In this investigation, 12 phytocompounds from S. suberectus were examined. Maackiain had the strongest affinity with the target protein 1ACJ, with a -10.3 Kcal/mol. When compared to the experimental medications Donepezil and Tacrine, all of these compounds had a higher binding affinity. In furthermore, in silico drug likeness and ADMET analyses of the phytochemicals demonstrated significant therapeutic advantages. As a conclusion, the present investigation would serve as a springboard for much more exploration to assess the phytocompounds' effectiveness against Alzheimer's disease complications.