We used medicinal plants for more than thousands of years to treat various diseases. They've always been a reliable supply of biologically active medications. WHO report states that nearly 80% of the population, especially in developing countries, rely on a traditional medical approach for healthy sustenance. The anticancer efficacy of various doses of ethanolic extract of Sida schimperiana was investigated experimentally using an in vitro approach. The results showed that different concentrations of the extracts have substantial anticancer efficacy. MTT assay was used to investigate the anticancer activity of an ethanolic extract of Sida schimperiana against the MDA MB 231 breast cancer cell line. The sample's IC50 value against breast cancer MDA MB 231 cell lines was 82.50g/ml. We observed significant findings, indicating that this herb can be used in traditional medicine.