Cytotoxic effect of antidiabetic drug glibenclamide on root meristem of Allium cepa l.
Savitha Rabeque C, Sangeetha R, Jelly Louis C
Diabetes is a commonly occurring disorder in many parts of the world. It is caused by other pre-disposing factors such as obesity, ageing and antigenic/antibody reaction. The acceptable medication for new cases of Diabetes mellitus is treatment with synthetic drug Glibenclamide. It is one of the most commonly used sulphonylureas in elderly patients with Type-2 diabetes,but the risk of severe or fatal hypoglycaemia is associated with the use of this drug which in- creases exponentially with age. Allium test is a sensitive test that has often been used for the determination of cytotoxic and genotoxic effects of Glibenclamide. On increasing the dosage from 20% to100% the gradual increase in effect was noted.The result illustrated that the Glibenclamide,reduce the number of dividing cells in root tip of Allium cepa.The study states that Glibenclamide even after treatment with various time schedule remains genotoxic as it has the ability to initiate the chromosomal aberrations of various types.
Savitha Rabeque C, Sangeetha R, Jelly Louis C. Cytotoxic effect of antidiabetic drug glibenclamide on root meristem of Allium cepa l.. International Journal of Botany Studies, Volume 7, Issue 1, 2022, Pages 383-387