Serum lipid profile of diabetic Albino mice treated with leaf methanolic extract of Syzygium caryophyllatum (L.) Alston and Syzygium densiflorum Wall
Savitha Rabeque C, S Padmavathy
Diabetes Mellitus is a major degenerative disorder that is characterized by hyperglycemia and hyperlipidemia which has been rated as a major contributing factors underlying the development of several metabolic diseases nowadays. The present study was carried out to assess the lipid profile of alloxan induced diabetic albino mice treated with leaf methanolic extract of Syzygium caryophyllatum and Syzygium densiflorum and standard glibenclamide, The serum concentration of cholesterol, HDL, LDL and triglycerides as well as body weight of all the animals in each group were determined after the 14th day of treatment. There was significant (P<0.001) reduction in body weight, serum cholesterol, LDL and Triglycerides when compared with the diabetic control mice. These reductions were dose dependent and compared well with values obtained in the standard drug treated control group. However, HDL-C level was lowered in the diabetic control and restored after the administration of the extracts at the dose of 250mg/kg b.w. and also in Group III treated with glibenclamide. The results showed that the leaf methanolic extract of Syzygium caryophyllatum is more potent than Syzygium densiflorum.