Plant invasion is an alarming concern in the tropical eco-climate, and creates an opportunistic advantage to mimic non-native climate conditions abruptly. Invasive plants possess a few marker allelochemicals that culminate in them for biological invasions to the non-native environment. The defense regulation of invasive plants mediated by the secretion of allelochemicals and interaction with peripheral native communities is fascinating to understand their successful establishment. Phyto and rhizo-secretions of allelopathic invaders and their antagonistic interaction with local plant communities navigate the entire process of native-invasive severance leading to causalities to regional flora of its vicinity betraying habitat and nutrient partitioning. The Indian subcontinent is a widespread hub of most of the dominant invasive plant species. Out of about 40% of alien plants occupying 8.5% of total vascular flora in India, invasive species are represented by 25% species out of the total species. The alleviated effects of allelochemicals secreted by some of the most obnoxious invasive species and their pervasive role in the native flora of India have been reviewed in this context.