Vitis vinifera L. (Family: Vitaceae), popularly known grape species, come from western Asia and southern Europe. V. vinifera contains flavonoids, anthocyanidins, phenolic compounds and stilbenoids. Each portion of the grapevine contained varying amounts of phytochemical substances. Different parts of this plant show Anti-inflammatory, Hepatoprotective, Antioxidant, Antidiabetic, Antiasthmatic, Antihypertensive, Anti-ischemic, Antimicrobial, Anti-aging, Anti-cancer, Anticataract, Antipyretic, Antinociceptive, Protection against bone loss, Anticholinergic, CNS protective, Anti-alzheimer, Anti-acne, Anti-sunburn, Antiplatelet, Wound healing, Antispasmodic, Anti-viral activity in SARS-CoV-2. Each pharmacological activity is determined by the phytochemical substances found in the grapevine, the components employed, and the extraction method used. This review covers different types, chemical constituents, and pharmacological actions of different parts of V. vinifera.