The current study was designed to examine the phytochemical constituents in the acetone extract of Melia azedarach, L. leaves through Gas Chromatography – Mass Spectrometry (GC-MS) and Fourier Transform – Infrared (FT-IR) spectroscopic analysis. Totally, about 28 phytocompounds were identified in GC - MS and the chromatogram graph showed relative peaks with individual compounds. The major phytocompounds with peak area percentage identified in the acetone extract were 2-methyl-Z,Z-3,13 (44.43%); n-hexadeconoic acid (21.83%); 2-pentanone,4-hydroxy-4-methyl- (10.05%); 3,7,11,15-tetramethyl-2-hexadecen-1-ol (4.08%); 2-furancarboxaldehyde,5-hydroxymethyl- (3.42%); octadecanoic acid (2.69%); 9-nonadecene (2.19%); dodecanoic acid (1.61%); phytol (1.29%); hydroquinone (1.25%). The presence of alcohol, alkane, aldehyde, conjugated alkene group, alkyl aryl, ether, primary alcohol and halo compound with stretching and bending functional groups were confirmed in the FT-IR analysis. The results obtained in the present study is an evident that, the phytocompounds present in acetone extract of M. azedarach leaves, might be a potential herbal alterative for various diseases and offers a base to take further investigation to find out its bioactivity and pharmaceutical importance.