The plant Sesbania grandiflora is an essential tree. This plant is used in Ayurvedic, Unani and Siddha medicine for various ailments. All the parts of the plant namely root, stem, bark, leaves, flowers, fruit are used as medicine, food and for other miscellaneous purposes. Traditionally this plant used for treatment of disease like diarrhea, dysentery, fever, cough and cold, and as tonic, expectorant etc. The antioxidant properties of Sesbania grandiflora are due to the presence of diverse types of phytochemical constituents. It also has pharmacological properties like anti-cancer, ant-helmintic, anti-diabetic, anti-ulcer, hepato-protective, anti-bacterial, anti-viral, hypolipidemic, anti-tuberculosis, cardio protective, anti-arthritic, immuno-modulatory, anti-inflammatory, analgesic, wound healing and as a tablet binder. There are various medicinal uses associated with this plant and out of these claims, some claims scientifically studied and reported. These observations are noteworthy for further studied on modern scientific lines.