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VOL. 7, ISSUE 2 (2022)
Catechin isolated from Withania coagulans modulates ethanol-induced inflammatory and apoptosis pathways in zebrafish liver
Authors
Y Swarnalatha, S Sivakkumar, Juliet
Abstract
Among life-threatening ailments, ethanol-induced liver is a major cause of deaths worldwide. The disease progression is a result of the increased permeability of intestine leading to inflammation and hepatotoxicity. Hence, in order to explore the possible cures or interventions to curtail disease progression, the present study evaluated the hepatoprotective and antioxidant activities of catechin (flavonoid) isolated from Withania coagulans in zebrafish. Catechin was isolated and purified using column chromatography, and molecular weight was determined through LCMS. Findings showed 0.5% of catechin was effective in hepatoprotective, hepatic antioxidant enzymes uplifting and minimizing inflammatory genes. This is due to membrane integrity and downregulating apoptotic genes. Normal anatomical features of hepatic tissue in the cathechin-treated group confirmed these observations. A high content of catechin in W. Coagulans helps improve the rate of recovery from ethanol-induced hepatotoxicity.
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Pages:197-203
How to cite this article:
Y Swarnalatha, S Sivakkumar, Juliet "Catechin isolated from <em>Withania coagulans</em> modulates ethanol-induced inflammatory and apoptosis pathways in zebrafish liver ". International Journal of Botany Studies, Vol 7, Issue 2, 2022, Pages 197-203
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