The leaves of Ziziphus xylopyrus having traditionally use as treatment of diabetes and hepatoprotective activity. The Ziziphus xylopyrus has limited gastrointestinal absorption because of its low bioavailability. Different flavonoids are slowly absorbed because the multi-ring compound. Many flavonoids they can cross lipid rich outer membrane of small intestine. The methanolic extract of phytosome was prepared in soya lecithin. Soya lecithin has antioxidant activity. Evaluation of phytosome for solubility study, Entrapment efficiency Transition temperature, X-ray diffraction, In vitro dissolution studies, FTIR study, an in vivo anti-diabetic activity of soya lecithin and Ziziphus xylopyrus can result in synergistic effect. Formulation of phytosome they can be loaded into capsule dosage form.