'Igatpuri' tehsil is 47KMs away from Nasik, near the 'Western Ghats of Maharashtra'. 'Igatpuri' has mix tribal population and this population is mostly relies on forest resources and livelihoods. Use of forest resources and forest products as a medicine is frequent. There dependency explored may plants as folk medicine. Field work was carried out in different regions of targeted area for the documentation of an ethnomedicinal plants. 51 angiosperm species were recorded, which were taxonomically classified under 27 families. In remote area of the tehsil, 80% medicinal need is fulfilled by direct use of folk medicinal plants. These plants are used to cure various ailments by tribal's of Igatpuri. But, since last few decades, the biodiversity of this area is disappearing at alarming rate. Our Traditional healers like Vaidu, Sadhu, Hakim, Baba was having excellent knowledge of use of regional indigenous plants species (ethnomedicinal plant species) than younger traditional new generation of Vaidu, Sadhu, Hakim and Babas. This indicates that the indigenous medicinal plant knowledge is declining day by day among the younger generation. This survey emphasis the urgent need of ‘regional community-based’ awareness and approach in conservation of indigenous regional flora or ethnomedicinal plants. Creating awareness among the local community as well as strategy makers is one of the most important task.