The documentation of the angiospermic plants species used among Irula, one of the ancient tribes of Palakkad district are limited compared to the extent of the variety of cultures and the diversity of plants of the region. This paper highlights, about 102 angiospermic plant species from 49 families, also their recorded and unrecorded indigenous ethanobotanical knowledge gained by Irula tribes through their experiences, practices and continues interaction with the nature. Of these, 37 species were used as edibles, 50 species were with medicinal properties and 4 plants were used for miscellaneous purposes including religious rituals and ceremonies. The study sought to establish the major threats to rich heritage of indigenous knowledge and the crucial need to study, authenticate, validate and document this fastly disappearing invaluable source of knowledge for upcoming generations.