The coronavirus disease 2019 (COVID–19) caused by the virus Severe Acute Respiratory Syndrome Corona Virus 2 (SARS–CoV–2) has has resulted in massive loss of valuable human lives, extensive destruction of livelihoods and financial crisis of unprecedented levels across the globe and declared a global pandemic in early 2020. The traditional medicine and ayurvedic therapy used in India since ancient times for its multifactorial pharmacological, medicinal, antimicrobial, immunomodulatory and adaptogenic effects, and even during current pandemic as well after recommendation of Ministry of AYUSH (Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homeopathy), Government if India. The commencement of 1206 Ayur Raksha Clinics and associated Task Forces in Indian states during 1st quarter of 2020 improves the reach and penetration of Ayurvedic preventive, therapeutic and convalescent care strategies for the COVID–19 pandemic. Keeping in view the immunomodulatory, immune system boosting and anti SARS–CoV–2 (anticovid) potential only best eight indigenous flora [Azadirachta indica A. Juss (Neem), Ocimum sanctum L. (Tulsi), Tinospora cordifolia Thunb. (Giloy), Withania somnifera L. (Ashwagandha), Piper betle L. (Betel vine), Cinchona officinalis L. (Kunain), Glycyrrhiza glabra L. (Liquorice) and Andrographis paniculata Burm. (Kalmegh)] Amongst several known and recommended medicinal plants were considered in the current manuscript. The ethnomedicinal, pharmacological and clinical significance of these medicinal floras well explored to prove the profound efficacy against SARS–CoV–2 and immunity boosting potential for strengthening of immune system and treatment of COVID–19. Thus, the espousal of the efficient medical flora as profound immunity booster in different formulation like oral pills, powder, decoction or even crude form in daily life is an utmost requirement for the improvement of immune system, treatment, prevention and control of COVID–19 infection.