Evaluating the growth, yield and seed quality of ten Quinoa (Chenopodium quinoa Willd.) genotypes planted in two different agro-ecological zones (EATU and TTHA) of Central Highlands, Vietnam showed that EATU-grown Moradas and Cahuil were significantly higher than other genotypes (above 142 cm), and taller than the highest genotypes Isluga, Moradas, Cahuil and Haiwan grown at TTHA (over 129 cm). At the harvest time, Cahuil also showed the biggest size of stem (14 mm) and number of branches per plant-1 (28.3 branches) when planting at EATU, whereas those were smaller at TTHA with above 12.4 mm and 27.2 branches recorded on Atlas and Moradas. The highest number of panicle plant-1 (over 33 panicles), and the greatest actual yield (above 1.9 ton ha-1) were observed on Atlas ad Cahuil when growing at EATU. In line with this, TTHA-grown Atlas, Cahuil expressed the heaviest weight of 1000 seeds (over 3 g), and the greatest yields (over 1.5 ton ha-1). Atlas and Cahuil also accumulated the highest content of protein (over 19.4 %) when growing in both agro-ecological zones. Noticeably, 70% of tested genotypes exhibited higher yields when growing at EATU compared to those grown at TTHA.