The effect of derivatives of sodium and potassium salts of 6-methyl-2-mercapto-4-hydroxypyrimidine (Methyur and Kamethur) and N-oxide-2,6-dimethylpyridine (Ivin) on growth and productivity of various cultivars of grain sorghum (Sorghum bicolor (L.) Moench) and sweet sorghum (Sorghum saccharatum (L.) Moench) was studied. It was found that soaking seeds with water solutions of Methyur, Kamethur and Ivin used at a concentration of 10-7M before sowing them into the soil contributed to improve the growth of sorghum and increase their productivity. The obtained results testify to the cultivar-dependent action of chemical compounds derivatives of pyrimidine and pyridine. The possibility of practical application of Methyur, Kamethur and Ivin as new effective regulators of sorghum growth is discussed.