A flowerless plant of Catharanthus roseus (L) G. Don was isolated by treating seeds with 0.4% NMU. The flowerless plant was medium tall, leaves curved clustered at the tip of stem, flowers absent. These variant was unable to set fruits and seeds. Therefore, multiple shoot were induced through direct organogenesis from the shoot tips of flowerless plant. The combination of 0.2 BAP, 1.0 kinetin and 0.05 mg/L NAA showed higher shoot induction and growth index. The roots were induced in MS medium supplemented with 0.5 mg/L IAA. Apical cell morphology study showed lack of differentiation of SAM into IAM. This depression caused by strong alkalyting action of NMU. A model explaining the phenomenon of flowering and nonflowering constructed, based on longitudinal section of stem going through apical dome.