Medicinal plants have been used for centuries and are used as a potential source of therapeutic drug. The present study deals with phytochemical screening and antioxidant potentials of leaves of cadaba fruticosa and Ocimum basilicum. Phytochemicals were extracted using one polar and one non-polar solvent like Ethanol and chloroform. Varying amount of alkaloids, phenols, flavonoids, Terpenoids etc were detected. Preliminary phytochemical screening shows notable presence of Alkaloids and Phenols and its quantitative estimation showed alkaloid components are much high as compared to Phenolics in both the extracts. Ethanolic extracts showed very good antioxidant properties compared to chloroform extract. These results are highly significant as they can pave the way for future scientific validation of the traditional knowledge of these potential medicinal plants.