Matricaria pubescens (Magnoliopsida: Asteraceae) is an important medicinal plant used in Algerian folk medicine as an antiinflammatory, analgesic and antiseptic. The present study was conducted on 16 males of Albino rabbits which were divided into four groups (a control group, a group envenomated by Cerastes cerastes venom, an envenomated group treated with venom and extract from medicinal plant Matricaria pubescens, and the last envenomated group treated with the anti-venom serum). Metabolic and histopathological changes were examined in different treated groups. The histological sections from tissues of different organs (liver, kidneys, lungs, muscles, heart, and brain) allowed us to observe a normal structure in all the organs of untreated rabbits unlike the treated ones. Our results showed a very highly significant increase in the concentrations of glycemia, urea, and creatinine in treated rabbits compared to the control. statistical analysis showed that there was a very highly significant (p = 0.0000) between all the groups in the increase of glucose, urea concentration, TGO and TGP and a highly significant in the creatinine (p = 0.0002) and the PTT (p = 0.0015). On the other hand, a very highly significant decrease in the total cholesterol, triglyceride, fibrinogen, and Prothrombin time of treated rabbits compared to those of the control. Statistical data confirmed that there was a very highly significant (p = 0.0000) between all the groups. According to the PCA analysis, the biological parameters (cholesterol, triglyceride, fibrinogen, and prothrombin time) were very close, a certain similarity was reflected between them which means that these parameters were influenced by each other. Same thing for the glycemia, urea, creatinine, GOT, GPT, and PTT.