Ethno pharmacological relevance: S. nigrum Linn. (Solanaceae) is a dicot weed that grows all over the world due to its not so specific water, temperature and mineral requirements, except polar and extreme desserts. Far and wide, different parts of this plant have been utilized conventionally to cure various maladies and ill health conditions such as cough, fever, joint pain, anemia, malaria, dressing wounds, burns, indigestion, rabies, insect or snake bite, diarrhea, dysentery, diabetes, asthma, lumbago, toothache, ophthalmic issues, cancer, tumors etc. Aim of the review: The foremost aim of this review paper is to come up with an overview and also to critically analyze the earlier reported ethno medicinal uses, phytochemistry, pharmacological properties and toxicological studies of S. nigrum. This paper will also serve the purpose to pinpoint the remaining gap, in addition to furnish a basis for future studies and investigations in above mentioned fields regarding this plant. Another lead motive of this review paper is to draw attention of researchers toward the extensive pharmaceutical values of this plant for their better implementation in upcoming times.