The present communication gives details about Mastitis disease of cow or milk giving animal. Which is the microorganism interaction or mammary gland infection.so milk giving animal mostly infected by this Mastitis disease so we are do the useful plant material to control this infection. Mastitis is a one of the major bacterial disease attacks on the milk cannel of Cow. Due to the development of this disease the quality & quantity of milk are Decrease. These disease Couse due to the bacteria pseudomonas aeruginosa Due to the development of these disease the quality & quantity of milk are Decrease. Due to the development of these disease the quality & quantity of milk are these diseases cause harmful effect on cattle. These diseases are cosmopolitan in distribution.