Objective: Find the knowledgeable Paliyar traditional healers in Meghamali, of Theni District, Tamil Nadu, India, and investigate their ethnomedical knowledge. Methods: Ten informants were questioned between October 2021 and September 2022 in a number of tribal settlements in the study area on how they used the native flora for therapeutic purposes. A modified questionnaire method was utilised to record information about the plants, including their local names, parts used and duration of medication. Results: A total of 45 plant species from 30 families and 45 genera were identified as having ethnomedicinal applications. Asteraceae, Euphorbiaceae, Acanthaceae and Apocynaceae were the four most significant families identified in our survey, each contributing three species. The leaves were most frequently employed to treat illnesses among the various plant parts that were utilised to make medicine. Conclusion: The Paliyar' tribal interest in ethnomedicine is reflected in their use of plants, and further study of these species could result in the identification of brand-new bioactive compounds.