Weed is one of the factors that cause low productivity of sweet corn. The presence of weeds in sweet corn areas can inhibit plant growth and affect sweet corn yields, which leads to competition for nutrients, water, and sunlight. This study aims to determine the effectiveness of the herbicide Mesotrione 60 g/l to control weeds in sweet corn plants. This research was conducted in a Bale Tatanen Faculty of Agriculture Padjadjaran University, Jatinangor, Sumedang Regency, West Java Province. The experimental design used was a randomized block design with seven treatments and four replications in order to obtain 28 experimental plots. The herbicide treatment of Mesotrione 60 g/l that tested was at a dose of 1,50 l/ha, 2,00 l/ha, 2,50 l/ha, 3,00 l/ha, 3,50 l/ha, manual weeding, and control. The results showed that the herbicide Mesotrion 60 g/l dose 2,00 l/ha - 3,00 l/ha effective and efficient in controlling total weeds in sweet corn cultivation up to 6 Weeks After Application, did not cause toxic symptoms in sweet corn plants, and increase the yield of corns.