Vitis vinifera L. (Draksha) is a generally known medicinal plant in the traditional medical system of Ayurveda. Vitis vinifera belongs to the Vitaceae (grape) family and is local to Europe and Central Asia. Maharashtra is the state with the largest grape production in India. V. vinifera is a widespread deciduous mountaineering plant. The maximum typically used part of the plant is the dried ripe fruit. Vitis vinifera contains large amounts of phytochemicals such as polyphenols, flavonoids, flavonols, anthocyanins, tannins, stilbenoids, and non-flavonoids. Draksha is widely used in the traditional Indian system of medicine Ayurveda for the treatment of a variety of diseases. Its compactness, consistency, flavor and variety have made it a popular finger food in countries around the world. In this article, a detailed literature review of the drug has been done in terms of its vernacular names, taxonomical hierarchy, habitat, botanical description, macroscopy, microscopy, chemical constituents, physicochemical parameters, phytochemical screening, pharmacological activities, ayurvedic aspects, marketed formulations, and patents filed on V. vinifera.