Tylophora indica (Burm.f) Merrill is pharmacologically important plant commonly known as Antmool or Indian ipecac, belongs to family Asclepeadiaceae. This plant is used for medicinal purposes in countries like India, Sri Lanka and Bangladesh. It is used to treat several disorders like bronchial asthma, respiratory disorders, cancer, skin disorders, cough, diarrhoea, microbial infection, inflammation. Many in vivo and in vitro studies revealed that this plant has potential for various pharmacological activities like antiasthmatic, anticancer, antimicrobial, antitumor, anti-inflammatory, antioxidant. Some alkaloids like tylophorine, tylophorinine, tylophorinidine are the important secondary metabolite which is isolated from leaves and roots of the plant. Tylophorine has been considered as a most active and explored compound. Apart from these compounds this plant is also having flavanoids, terpenoids, and sterols. This review provides the comprehensive account on the morphology, phytochemistry, medicinal value and the biotechnological aspects of Tylophora indica. This compiled study provide the information about the recent trends and techniques applied on Tylophora many of them have yet to be explored.