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VOL. 9, ISSUE 12 (2024)
Study on phytochemical diversity of Lamiaceae: Promising leads in anti-malarial drug development
Authors
Priyanka Joshi, Shilpi Rawat, Pankaja Pandey, Abhay chaturvedi, Subhash Chandra
Abstract
Malaria a health ailment primarily caused by Plasmodium falciparum,
remains a global health challenge. The urgent need for new drugs and
therapeutics has shifted the focus to natural products derived from medicinal
plants. The Lamiaceae family is known for its wide ethno medicinal use and rich
phytochemical diversity, holds a significant potential in anti- malarial
research. This paper reviews the bioactive compounds of the Lamiaceae family.
These compounds possess different mechanisms of action against P. falciparum,
including destruction of parasite membranes, inducing oxidative stress,
altering of heme detoxification, and interference with critical enzymes.
Compounds like rosmarinic acid, thymol, carvacrol and essential oils from
species such as Ocimum gratissimum and Thymus vulgaris, have
shown significant anti-plasmodial properties in vitro. Also, the
synergistic potential of these compounds with known anti-malarial drugs
enhances their therapeutic value, potentially lowering resistance development.
However, challenges such as difference in phytochemical composition,
availability, and lesser in vivo and clinical studies must be addressed
to fully recognise their potential. This review highlights the pharmaceutical
promise of Lamiaceae derived compounds as anti-malarial agents. Bridging the
gap between traditional medicinal knowledge and modern pharmacological
practices could lead to innovative findings in the combat against malaria and
drug resistance.
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Pages:20-25
How to cite this article:
Priyanka Joshi, Shilpi Rawat, Pankaja Pandey, Abhay chaturvedi, Subhash Chandra "Study on phytochemical diversity of Lamiaceae: Promising leads in anti-malarial drug development". International Journal of Botany Studies, Vol 9, Issue 12, 2024, Pages 20-25
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