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VOL. 9, ISSUE 8 (2024)
In vitro phytochemical screening, antioxidant activity and cytotoxicity of Coffea liberica ethanolic leaf extract
Authors
Dorothy Liz June M Baay, Rod Vincent Borromeo, Florifern C Paglinawan
Abstract
Coffea liberica are
small trees, native from the Ethiopian mountains and varieties grow in tropical
and sub-tropical areas. It is one of the 6500 species one of the largest plant
family, the family Rubiaceae. Coffea plant species are known to carry a
bioactive chemical caffeine and and related species are known to be positive in
polyphenols and tannin. This study investigates the phytochemical contituents,
antioxidant activity and cytotoxicity in one of the Coffea plant species, the Coffea
liberica leaf in ethanolic extract. Phytochemical screening showed
high concentration of alkaloids, flavonoids and saponins. DPPH (1,
1-diphenyl-2-picrylhydrazyl) free radical scavenging activity possess poor free
radical scavenging activity with LC50 value of 33.48 μg/mL and is somehow
dependent to concentration. Cytotoxicity test, using brine shrimp lethality
assay, also showed potent and active effects with an LC50 value of
74.16ppm. The result shows the present bioactive compounds found in the leaf
extract of Coffea liberica and its effective anti-oxidative and
cytotoxic property. These results are promising and can be a useful reference
for future studies especially in the field of medicine and pharmaceuticals.
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Pages:31-35
How to cite this article:
Dorothy Liz June M Baay, Rod Vincent Borromeo, Florifern C Paglinawan "<i>In vitro</i> phytochemical screening, antioxidant activity and cytotoxicity of <i>Coffea liberica </i>ethanolic leaf extract". International Journal of Botany Studies, Vol 9, Issue 8, 2024, Pages 31-35
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